Myeloproliferative Neoplasms (Online CE Course)

(based on 293 customer ratings)

Author: Leah Coppolino, MPH, CLS(NCA), MT(ASCP)
Reviewer: Rebecca J. Laudicina, PhD, MLS(ASCP)^CM & Rory Huschka, M.Ed., MT(ASCP)

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This course describes the 2008 World Health Organization classification system for myeloproliferative neoplasms (MPNs). The different types of MPNs are compared and contrasted based upon etiology and patient symptoms. Hematologic, cytogenetic, and other laboratory features associated with specific MPNs are presented in this course along with a list of common treatment options.

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)

Approved through 4/30/2023

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Hematology): 1 hour(s)

Approved through 9/1/2022

Objectives

Describe the World Health Organization classification system for myeloproliferative neoplasms (MPNs).
Compare and contrast the types of MPNs based upon etiology and patient symptoms.
Discuss the hematologic, cytogenetic, and other laboratory features associated with specific MPNs.
List common treatment options.

Customer Ratings

(based on 293 customer ratings)

Course Outline

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Myeloproliferative Neoplasms

Introduction to Myeloproliferative Neoplasms (MPNs)
Classification of Myeloproliferative Neoplasms (MPNs)
Pathophysiology of Myeloproliferative Neoplasms (MPNs)
Symptoms
Match the myeloproliferative neoplasm with the cell line that is most affected.

Chronic Myeloid Leukemia

Chronic Myeloid Leukemia (CML)
CML and the Philadelphia Chromosome
Laboratory Investigation of CML
CML Peripheral Blood Smear
Progression of CML
Treatment of CML
The Philadelphia chromosome, associated with chronic myeloid leukemia (CML), involves a reciprocal translocation of genes from which two chromosomes?

Chronic Neutrophilic Leukemia

Chronic Neutrophilic Leukemia (CNL)
Chronic Neutrophilic Leukemia (CNL), continued

Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia

Hypereosinophilic Syndrome (HES)
Chronic Eosinophilic Leukemia (CEL)
What causes the characteristic heart and/or lung damage frequently demonstrated in patients with chronic eosinophilic leukemia?

Essential Thrombocythemia

Essential Thrombocythemia (ET)
Diagnosis of Essential Thrombocythemia (ET)
Diagnosis of Essential Thrombocythemia (ET): Bone Marrow Findings
Essential Thrombocythemia (ET) Diagnosis
ET Treatment
Which of the following thrombocytic characteristics are often associated with essential thrombocythemia (ET)?

Primary Myelofibrosis

Primary Myelofibrosis (PMF)
Diagnosis of Primary Myelofibrosis (PMF)
Diagnosis of Primary Myelofibrosis: World Health Organization (WHO) Criteria
Which of the following red blood cell morphologic features is associated with primary myelofibrosis?

Polycythemia Vera

Polycythemia Vera (PV)
Diagnosis of Polycythemia Vera (PV)
Treatment of Polycythemia Vera
Which type of anemia can be caused by the common treatment for polycythemia vera, which is used to manage patient symptoms?

Myeloproliferative Neoplasm, Unclassifiable (MPN-u)

Myeloproliferative Neoplasms, Unclassifiable (MPD-u)

Summary

Table: Laboratory Findings Associated with Myeloproliferative Neoplasms (MPNs)

References

References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.

Author information: Leah Coppolino, MPH, MLS(ASCP)^CM is a Program Director at MediaLab, Inc. Previously, she was the Director of the Medical Laboratory Science Program at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.

Reviewer information: Rebecca J. Laudicina, PhD, MLS(ASCP)^CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and PhD in Educational Psychology from Temple University. She is the author of numerous hematology-related publications.

Reviewer information: Rory Huschka, M. Ed., MT(ASCP), has over 20 years of experience as a medical technologist, technical supervisor, professor, and manager. He is the former Director of Clinical Laboratory Science and Medical Laboratory Technician Programs at Brookline College. He is currently a Program Director at MediaLab, Inc. Rory holds a BS degree in Medical Technology from North Dakota State University and a Masters in Educational Leadership from Argosy University. He has also completed the Six Sigma Green Belt training at Villanova University.