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Myeloproliferative Neoplasms (Online CE Course)

(based on 363 customer ratings)

Author: Leah Coppolino, MPH, CLS(NCA), MT(ASCP)
Reviewer: Rebecca J. Laudicina, PhD, MLS(ASCP)CM

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Course number 578-011-17, approved through 2/28/2019
Course number 20-547797, approved through 9/1/2018

Objectives

  • Describe the 2008 World Health Organization classification system for myeloproliferative neoplasms (MPNs).
  • Compare and contrast the types of MPNs based upon etiology and patient symptoms.
  • Discuss the hematologic, cytogenetic, and other laboratory features associated with specific MPNs.
  • List common treatment options.

Customer Ratings

(based on 363 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Myeloproliferative Neoplasms
    • Chronic Myeloid Leukemia
      • Chronic Myeloid Leukemia (CML)
      • CML and the Philadelphia Chromosome
      • Laboratory Investigation of CML
      • CML Peripheral Blood Smear
      • Progression of CML
      • Treatment of CML
      • The Philadelphia chromosome, associated with chronic myeloid leukemia (CML), involves a reciprocal translocation of genes from which two chromosomes?
    • Chronic Neutrophilic Leukemia
    • Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia
      • Hypereosinophilic Syndrome (HES)
      • Chronic Eosinophilic Leukemia (CEL)
      • What causes the characteristic heart and/or lung damage frequently demonstrated in patients with chronic eosinophilic leukemia?
    • Essential Thrombocythemia
      • Essential Thrombocythemia (ET)
      • Diagnosis of Essential Thrombocythemia (ET)
      • Diagnosis of Essential Thrombocytosis (ET): Bone Marrow Findings
      • Essential Thrombocytosis (ET) Diagnosis
      • ET Treatment
      • Which of the following thrombocytic characteristics are often associated with essential thrombocytosis (ET)?
    • Primary Myelofibrosis
      • Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis: World Health Organization (WHO) Criteria
      • Which of the following red blood cell morphologic features is associated with primary myelofibrosis?
    • Polycythemia Vera
    • Myeloproliferative Neoplasm, Unclassifiable (MPN-u)
      • Myeloproliferative Neoplasms, Unclassifiable (MPD-u)
  • Summary
      • Table: Laboratory Findings Associated with Myeloproliferative Neoplasms (MPNs)
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.
 
Author information: Leah Coppolino, MPH, CLS(NCA), MT(ASCP) is the Director of Education and Outreach in the Department of Pathology and Laboratory Medicine at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.
 
Reviewer information: Rebecca J. Laudicina, PhD, MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and PhD in Educational Psychology from Temple University. She is the author of numerous hematology-related publications.

BM biopsy megakayocytes abnormal
Chronic Myelogenous Leukemia. Peripheral Blood Smear.
Image Credit: Paulo Henrique Orlandi Mourao
Bacterial infection, many neutrophils
CML
CMLspread
pt16-basophil
therapeutic phlebotomy from ITXMdiagnostics website with permission 8-2014 LC

Keywords

These are the most common topics and keywords covered in Myeloproliferative Neoplasms:

thrombocythemia aspiration anemia breathunexplained cure thromboplastin extramedullary acute hematopoietic dysplastic diseases polycythemia syndrome chromosomes health platelets hypercellularity laboratory splenomegaly neutrophilic chemotherapy stem neoplastic alkaline peripheral blood smear linechronic jak2 clonality thrombopoietin diagnostic clumps poikilocytosis leukemia answers diphosphate abnormal myelodysplastic megakaryocytes criterion lhemoglobin immature cavity abl1 granulocytic fibrous cutaneous myelogenous erythroid exon platelet unsuccessful hypercellular precursors leukemic iron interferon cancer mpns somatic thrombotic erythropoietin wbcs adenosine unclassifiable red blood cell myelofibrosisfibroblastpolycythemia disorders cellular thrombocytosis turnover epinephrine over-proliferation myelofibrosis leukocyte transformation progenitor morphology symptoms deficiency megakaryocytic eosinophilia myeloproliferative malignant chromosome protocols aggregation evaluation tryptase calreticulin conditions recommends treatment myeloiderythroid mutation prefibrotic tyrosine myeloid cytogenetic mpn-u megakaryocyte dysplasia subtype abnormality lplatelet mastocytosis biopsy hypereosinophilic karyotypic low-dose fibrosis heart lineage serum lymphoblastic clinical translocation gene reactive cellularity diagnose dehydrogenase phosphatase bleedingpetechiaenight hepatosplenomegaly erythrocytic hematopoiesis neutrophils neoplasm lung asymptomatic red blood cells neoplasmmost blood philadelphia bone marrow numbers wright-stained indolent eosinophil thrombopoeitinusually mast cells erythrocytosis lymphocytic clonal erythrocyte neoplasms neutrophilia cells kinase abnormalities phlebotomy hydroxyurea eosinophils lactate reticulin diagnosis granulocytes eosinophilic losseasy disease cobalamin prothrombin cancertopics monocytes hemoglobin aspirate clones basophils hematologic fibrotic hematocrit ratio transformational mast cell includenormal
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BM biopsy megakayocytes abnormal


Chronic Myelogenous Leukemia. Peripheral Blood Smear.
Image Credit: Paulo Henrique Orlandi Mourao


Bacterial infection, many neutrophils


CML


CMLspread


pt16-basophil


therapeutic phlebotomy from ITXMdiagnostics website with permission 8-2014 LC