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Myeloproliferative Neoplasms (Online CE Course)

(based on 387 customer ratings)

Author: Leah Coppolino, MPH, CLS(NCA), MT(ASCP)
Reviewer: Rebecca J. Laudicina, PhD, MLS(ASCP)CM

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Course number 578-011-17, approved through 2/28/2019
Course number 20-547797, approved through 9/1/2020

Objectives

  • Describe the 2008 World Health Organization classification system for myeloproliferative neoplasms (MPNs).
  • Compare and contrast the types of MPNs based upon etiology and patient symptoms.
  • Discuss the hematologic, cytogenetic, and other laboratory features associated with specific MPNs.
  • List common treatment options.

Customer Ratings

(based on 387 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Myeloproliferative Neoplasms
    • Chronic Myeloid Leukemia
    • Chronic Neutrophilic Leukemia
      • Chronic Neutrophilic Leukemia (CNL)
      • Chronic Neutrophilic Leukemia (CNL), continued
    • Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia
      • Hypereosinophilic Syndrome (HES)
      • Chronic Eosinophilic Leukemia (CEL)
      • What causes the characteristic heart and/or lung damage frequently demonstrated in patients with chronic eosinophilic leukemia?
    • Essential Thrombocythemia
    • Primary Myelofibrosis
      • Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis: World Health Organization (WHO) Criteria
      • Which of the following red blood cell morphologic features is associated with primary myelofibrosis?
    • Polycythemia Vera
      • Polycythemia Vera (PV)
      • Diagnosis of Polycythemia Vera (PV)
      • Treatment of Polycythemia Vera
      • Which type of anemia can be caused by the common treatment for polycythemia vera, which is used to manage patient symptoms?
    • Myeloproliferative Neoplasm, Unclassifiable (MPN-u)
      • Myeloproliferative Neoplasms, Unclassifiable (MPD-u)
  • Summary
      • Table: Laboratory Findings Associated with Myeloproliferative Neoplasms (MPNs)
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.
 
Author information: Leah Coppolino, MPH, CLS(NCA), MT(ASCP) is the Director of Education and Outreach in the Department of Pathology and Laboratory Medicine at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.
 
Reviewer information: Rebecca J. Laudicina, PhD, MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and PhD in Educational Psychology from Temple University. She is the author of numerous hematology-related publications.

BM biopsy megakayocytes abnormal
Chronic Myelogenous Leukemia. Peripheral Blood Smear.
Image Credit: Paulo Henrique Orlandi Mourao
Bacterial infection, many neutrophils
CML
CMLspread
pt16-basophil
therapeutic phlebotomy from ITXMdiagnostics website with permission 8-2014 LC

Keywords

These are the most common topics and keywords covered in Myeloproliferative Neoplasms:

platelets hematopoiesis thrombotic lung granulocytic health biopsy criterion hypercellular stem transformational hypercellularity hepatosplenomegaly ratio evaluation aggregation diagnose reticulin iron hematopoietic leukocyte poikilocytosis low-dose answers calreticulin neoplasms abnormal progenitor abl1 megakaryocytic adenosine myeloproliferative leukemic precursors mpn-u erythrocyte serum turnover kinase unclassifiable erythropoietin polycythemia red blood cells conditions neutrophilic lhemoglobin blood aspirate cancertopics thrombocythemia phlebotomy abnormality myeloid chemotherapy basophils megakaryocytes thromboplastin clinical fibrosis wbcs hypereosinophilic disease hemoglobin lplatelet fibrotic epinephrine jak2 subtype prefibrotic cellularity diseases tryptase diphosphate leukemia mpns over-proliferation heart erythrocytic extramedullary clonality asymptomatic platelet diagnosis alkaline indolent unsuccessful includenormal disorders syndrome hematocrit cavity prothrombin interferon reactive eosinophils eosinophilic losseasy cancer protocols clones mastocytosis cells translocation myelofibrosisfibroblastpolycythemia mast cells granulocytes cure myeloiderythroid treatment lactate dysplasia thrombopoeitinusually hydroxyurea chromosomes dysplastic erythroid neutrophilia neoplasm cytogenetic mast cell exon clumps lineage deficiency transformation diagnostic laboratory immature monocytes myelogenous lymphocytic numbers eosinophil symptoms neoplastic karyotypic recommends cobalamin hematologic neoplasmmost breathunexplained red blood cell bone marrow aspiration myelodysplastic peripheral blood smear anemia philadelphia cellular gene acute abnormalities bleedingpetechiaenight morphology fibrous wright-stained linechronic tyrosine thrombocytosis somatic dehydrogenase malignant eosinophilia erythrocytosis neutrophils splenomegaly clonal mutation cutaneous thrombopoietin myelofibrosis megakaryocyte chromosome phosphatase lymphoblastic
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BM biopsy megakayocytes abnormal


Chronic Myelogenous Leukemia. Peripheral Blood Smear.
Image Credit: Paulo Henrique Orlandi Mourao


Bacterial infection, many neutrophils


CML


CMLspread


pt16-basophil


therapeutic phlebotomy from ITXMdiagnostics website with permission 8-2014 LC