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Myeloproliferative Neoplasms (Online CE Course)

(based on 391 customer ratings)

Author: Leah Coppolino, MPH, CLS(NCA), MT(ASCP)
Reviewer: Rebecca J. Laudicina, PhD, MLS(ASCP)CM

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Course number 578-011-17, approved through 2/28/2019
Course number 20-547797, approved through 9/1/2020

Objectives

  • Describe the 2008 World Health Organization classification system for myeloproliferative neoplasms (MPNs).
  • Compare and contrast the types of MPNs based upon etiology and patient symptoms.
  • Discuss the hematologic, cytogenetic, and other laboratory features associated with specific MPNs.
  • List common treatment options.

Customer Ratings

(based on 391 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Myeloproliferative Neoplasms
    • Chronic Myeloid Leukemia
    • Chronic Neutrophilic Leukemia
      • Chronic Neutrophilic Leukemia (CNL)
      • Chronic Neutrophilic Leukemia (CNL), continued
    • Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia
      • Hypereosinophilic Syndrome (HES)
      • Chronic Eosinophilic Leukemia (CEL)
      • What causes the characteristic heart and/or lung damage frequently demonstrated in patients with chronic eosinophilic leukemia?
    • Essential Thrombocythemia
    • Primary Myelofibrosis
      • Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis: World Health Organization (WHO) Criteria
      • Which of the following red blood cell morphologic features is associated with primary myelofibrosis?
    • Polycythemia Vera
      • Polycythemia Vera (PV)
      • Diagnosis of Polycythemia Vera (PV)
      • Treatment of Polycythemia Vera
      • Which type of anemia can be caused by the common treatment for polycythemia vera, which is used to manage patient symptoms?
    • Myeloproliferative Neoplasm, Unclassifiable (MPN-u)
      • Myeloproliferative Neoplasms, Unclassifiable (MPD-u)
  • Summary
      • Table: Laboratory Findings Associated with Myeloproliferative Neoplasms (MPNs)
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.
 
Author information: Leah Coppolino, MPH, CLS(NCA), MT(ASCP) is the Director of Education and Outreach in the Department of Pathology and Laboratory Medicine at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.
 
Reviewer information: Rebecca J. Laudicina, PhD, MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and PhD in Educational Psychology from Temple University. She is the author of numerous hematology-related publications.

BM biopsy megakayocytes abnormal
Chronic Myelogenous Leukemia. Peripheral Blood Smear.
Image Credit: Paulo Henrique Orlandi Mourao
Bacterial infection, many neutrophils
CML
CMLspread
pt16-basophil
therapeutic phlebotomy from ITXMdiagnostics website with permission 8-2014 LC

Keywords

These are the most common topics and keywords covered in Myeloproliferative Neoplasms:

neutrophilia diphosphate low-dose myeloid precursors peripheral blood smear platelets somatic kinase myeloproliferative exon cobalamin abnormal malignant red blood cell megakaryocyte turnover mastocytosis treatment diagnostic lineage diagnose diseases neoplasms thromboplastin reticulin indolent lplatelet fibrosis monocytes erythroid lymphocytic protocols disorders heart ratio lactate lhemoglobin answers philadelphia megakaryocytic bone marrow disease clonality tryptase myelofibrosis myelofibrosisfibroblastpolycythemia erythrocyte abl1 aggregation includenormal cancer polycythemia hematocrit morphology over-proliferation splenomegaly thrombocythemia hepatosplenomegaly myelogenous symptoms mast cells cellularity leukemia lymphoblastic reactive diagnosis myeloiderythroid erythrocytic losseasy immature thrombopoeitinusually alkaline asymptomatic thrombotic chemotherapy unclassifiable megakaryocytes abnormality wright-stained hypereosinophilic poikilocytosis neutrophilic cells thrombopoietin myelodysplastic clumps calreticulin platelet aspiration lung eosinophilic basophils karyotypic subtype serum breathunexplained anemia hemoglobin erythrocytosis clonal neoplasm linechronic phosphatase laboratory mpn-u progenitor erythropoietin stem abnormalities leukocyte criterion jak2 hypercellularity mpns conditions granulocytic health interferon phlebotomy cancertopics acute cutaneous evaluation neoplasmmost iron biopsy translocation aspirate prothrombin extramedullary mast cell unsuccessful chromosome neoplastic clinical fibrous eosinophils eosinophil epinephrine eosinophilia cytogenetic hematopoiesis leukemic granulocytes dehydrogenase cure cavity transformation recommends hydroxyurea fibrotic dysplastic deficiency hematologic bleedingpetechiaenight tyrosine hypercellular cellular wbcs prefibrotic adenosine gene chromosomes dysplasia transformational neutrophils mutation numbers blood hematopoietic red blood cells clones thrombocytosis syndrome
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BM biopsy megakayocytes abnormal


Chronic Myelogenous Leukemia. Peripheral Blood Smear.
Image Credit: Paulo Henrique Orlandi Mourao


Bacterial infection, many neutrophils


CML


CMLspread


pt16-basophil


therapeutic phlebotomy from ITXMdiagnostics website with permission 8-2014 LC