Course Outline
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- Overview of Rh
- Practice questions
- Rh typing is considered extremely important in pre-transfusion testing because:
- The antibody that reacts with most D-positive red blood cells (RBCs), weakly with D-negative RBCs and NEVER with Rhnull RBCs is:
- Genetics/biochemistry
- Nomenclature or terminology and inheritance in the Rh system
- Practice questions
- Which of the following are terminologies used for the Rh blood group system?
- Using Rosenfield terminology and the possible answers below, select the correct way to write the phenotype for a red cell sample that reacts as follow...
- Match the correct Wiener shorthand with the Fisher-Race designation provided.
- From the choices given below, select the most likely Fisher-Race designation for the individual whose red cells test as follows:D +C+E negc +e+
- Rh system antigens and several important genetic alterations
- Rh Antigens of Clinical Importance
- Alterations in D Antigen Expression
- Four Mechanisms of Weakened Expression of the D Antigen
- Mechanism 1: C in trans to RHD
- Mechanism 2: Weak D
- Mechanism 3: Partial D
- Mechanism 4: Del
- Deletion, null and mod Phenotypes in the Rh System
- Inheritance of the Rhnull and Rhmod Phenotypes
- Other Unusual Phenotypes and Rare Alleles in the Rh System
- Practice questions
- Select all items from the list below representing mechanisms that will result in weakened expression of the D antigen.
- From the list below, select all of the items that represent null or deletion phenotypes.
- Characteristics of Rh system antibodies
- Laboratory testing for Rh system antigens and antibodies
- Practice questions
- Reagents manufactured from a single clone of antibody-producing cells are called:
- Which of the following situations can result in a false-negative reaction with Rh typing reagents?
- Clinical considerations related to the Rh system
- Practice questions
- From the choices below, select all the reasons Rh antibodies are clinically significant.
- A common practice for preparing red blood cell products for chronically transfused patients is to match Rh phenotype of recipient and donor by testing...
- Case study
- Rh Case Study
- Discussion of Rh Case Study
- Rh Case Study, Further Testing
- Rh Case Study, ID Panel crossout
- Further Discussion of Rh Case Study
- References
Additional Information
Level of Instruction: Intermediate
Intended audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.
Author information: Pamela Inglish, MT (ASCP)SBB has 30+ years of experience in medical laboratory sciences having completed training at the Medical College of Virginia/Virginia Commonwealth University. Subsequently, she obtained certification as a Specialist in Blood Banking through AABB/ASCP. For the majority of her career, Ms. Inglish held positions of responsibility in hospital transfusion services, blood centers, and clinical stem cell transplant processing laboratories and has also sold clinical lab diagnostic equipment and reagents. In her most recent position at the University of Cincinnati/Hoxworth Blood Center, she was director of quality assurance and education and served as an adjunct instructor.
Reviewer information: Jessica M. Mantini, MS, MLS(ASCP)CM, is a clinical instructor of Immunohematology at the Ohio State University School of Allied Medical Professions and the Program Director for the Medical Laboratory Science Division. She holds an MS in Allied Health Management from Ohio State University.
Suzanne H. Butch, MA, MLS(ASCP)CM, SBB, DLM is currently working on special projects for the Department of Pathology at Michigan Medicine in Ann Arbor, Michigan. She formerly worked in Quality Assurance in the Department of Pathology and as the Administrative Manager for Healthcare, Blood Bank & Transfusion Service at the University of Michigan Hospitals and Health Centers in Ann Arbor, Michigan. She holds a Bachelors in Medical Technology from the University of Michigan, a Masters Degree in Management and Supervision from Central Michigan University, and Certifications as a Specialist in Blood Bank, as a Quality Audit and as a Diplomate in Laboratory Medicine.