Course Outline
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- Introduction
- Introduction
- HH is the most common cause of which of the following conditions?
- Normal Iron Metabolism
- Overview of Iron Metabolism
- Storage Iron
- Iron Intake and Recycling
- Regulation of Iron Equilibrium
- Iron Transport
- Which compound normally contains the majority of the body's total iron?
- What is a mobilizable, water-soluble form of storage iron bound to protein?
- What percentage of dietary iron is normally absorbed daily?
- True or False: Decreased hepcidin levels are related to increased iron absorption into the bloodstream.
- What is the protein that carries iron in the blood plasma?
- Pathophysiology of Iron Overload in HH
- Mutations Associated with HH
- HFE and Other Genes
- Specific HFE Mutations
- Epidemiology of HFE Mutations
- Incomplete Penetrance
- Prevalence of HFE Mutations
- Mutations in which gene account for the majority of cases of HH?
- True or False: In C282Y mutation, the HFE protein's function is altered due to binding with beta-2 microglobulin decreasing and HFE remaining within t...
- Which genotype accounts for the most significant percentage of cases of HH?
- Diagnosis
- General Clinical Considerations
- Signs and Symptoms of HH
- Diagnosing HH
- Example of a Testing Algorithm for HH
- Which of the following characterizes the early signs and symptoms of HH?
- Which of the following are needed for a diagnosis of HH?
- Laboratory Testing for HH
- Treatment and Management of HH
- Rationale for Treatment
- Initial Treatment
- Maintenance Therapy
- Other Treatments
- Prognosis and Mortality
- What is a typical schedule for phlebotomy during the initial treatment phase for HH?
- What drug may be used to decrease iron levels in patients with iron overload?
- How long should therapy continue for patients with HH?
- What is the major determinant of prognosis for patients with HH?
- Case Study
- Case StudyAndrew is a 49-year-old Caucasian male seen by a primary care doctor. He reports that for the last 1-2 years or longer, he has experienced m...
- Case Study continuedAndrew is a 49-year-old Caucasian male seen by a primary care doctor. He reports that for the last 1–2 years or longer, he h...
- Case Study, continuedAndrew is a 49-year-old Caucasian male seen by a primary care doctor. He reports that for the last 1–2 years or longer, he ...
- References
Additional Information
Level of instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, pathology residents, MLS students, and other health care personnel who have an interest in this subject matter.
Author Information: Rebecca J. Laudicina, Ph.D., MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and Ph.D. in Educational Psychology from Temple University. She is the author of numerous publications including many in the field of hematology.
Reviewer Credentials:
Vicky LeGrys, DA, MLS(ASCP)CM is a professor in the Division of Clinical Laboratory Science in the School of Medicine at the University of North Carolina Chapel Hill where she is responsible for the lecture and laboratory courses in Biochemistry, Clinical Chemistry, and Quality Assurance. She holds a Doctorate of Arts and a Master of Science in Medical Technology from the Catholic University of America, Washington DC with a major in Clinical Chemistry.
Laurie Bjerklie, M.A., MLS(ASCP)CM is currently a Content Developer for MediaLab and LabCE. She has been
in higher education for over 14 years, has been a professor in both MLT and MLS
programs, and served as a Program Director.
Course Description: This course offers an in-depth look at the condition of hemochromatosis. It begins with a discussion about normal iron metabolism and continues by explaining the pathophysiology of iron overload that occurs in the condition of hemochromatosis. Clinical considerations and laboratory testing are also discussed.
