Hereditary Hemochromatosis (Online CE Course)

(based on 291 customer ratings)

Author: Rebecca J. Laudicina, Ph.D., MLS(ASCP)CM
Reviewer: Vicky LeGrys, DA, MLS(ASCP)CM and Laurie Bjerklie MA, MLS(ASCP)CM

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Hereditary hemochromatosis is a disorder of iron regulation that can over time lead to widespread organ damage, a variety of chronic disorders, and even death. Early detection may permit treatment before the development of substantial iron overload. The laboratory technologist plays a major role in detecting and controlling this disease. In this course, you will learn about the basics of iron metabolism, the signs and symptoms of hemochromatosis, how it is treated, and the laboratory tests and procedures that are vital to its diagnosis and maintenance.

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Approved through 8/31/2024
Approved through 8/31/2024

Objectives

  • Describe basic aspects of normal iron metabolism.
  • Explain the pathophysiology of iron overload associated with hereditary hemochromatosis (HH).
  • Discuss mutations associated with HH, including prevalence in various ethnic groups and penetrance.
  • List early and late clinical signs and symptoms of HH.
  • Evaluate screening and confirmatory laboratory tests used in detection and diagnosis of iron overload and HH.
  • Describe initial and long-term treatment and management options for HH.

Customer Ratings

(based on 291 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Introduction
      • Introduction
      • HH is the most common cause of which of the following conditions?
  • Normal Iron Metabolism
      • Overview of Iron Metabolism
      • Storage Iron
      • Iron Intake and Recycling
      • Regulation of Iron Equilibrium
      • Iron Transport
      • Which compound normally contains the majority of the body's total iron?
      • What is a mobilizable, water-soluble form of storage iron that is bound to protein?
      • What percentage of dietary iron is normally absorbed daily?
      • Decreased levels of hepcidin are related to increased iron absorption into the bloodstream.
      • What is the protein that carries iron in the blood plasma?
  • Pathophysiology of Iron Overload in HH
  • Mutations Associated with HH
      • HFE and Other Genes
      • Specific HFE Mutations
      • Epidemiology of HFE Mutations
      • Incomplete Penetrance
      • Prevalence of HFE Mutations
      • Mutations in which gene account for the majority of cases of HH?
      • In C282Y mutation, the function of HFE protein is altered as a result of binding with beta-2 microglobulin becoming decreased and HFE remaining within...
      • Which genotype accounts for the greatest percentage of cases of HH?
  • Diagnosis
      • General Clinical Considerations
      • Signs and Symptoms of HH
      • Diagnosing HH
      • Example of a Testing Algorithm for HH
      • Which of the following characterizes the early signs and symptoms of HH?
      • Which of the following are needed for a diagnosis of HH?
  • Laboratory Testing for HH
      • General Overview of Laboratory Testing
      • Serum Iron (SI)
      • Transferrin (Tf) and Total Iron Binding Capacity (TIBC)
      • Transferrin Saturation (TS)
      • Serum Ferritin (SF)
      • Unsaturated Iron Binding Capacity (UIBC)
      • Molecular Tests for Genetic Mutations
      • Definitive Tests for Iron Overload
      • Quantitative Phlebotomy
      • Screening for Hereditary Hemochromatosis
      • What laboratory test reflects circulating iron that is bound to transferrin?
      • What would you expect the serum iron (SI) and total iron binding capacity (TIBC) to be in a person with HH?
      • Which laboratory assay is considered to be a confirmatory test for HH?
      • Why is serum ferritin (SF) a less than optimal screening test for HH?
      • What unsaturated iron binding capacity (UIBC) result is consistent with a diagnosis of HH?
      • Which statement best describes the use of the liver biopsy in suspected cases of HH?
  • Treatment and Management of HH
      • Rationale for Treatment
      • Initial Treatment
      • Maintenance Therapy
      • Other Treatments
      • Prognosis and Mortality
      • What is a typical schedule for phlebotomy during the initial treatment phase for HH?
      • What drug may be used to decrease iron levels in patients with iron overload?
      • How long should therapy continue for patients with HH?
      • What is the major determinant of prognosis for patients with HH?
  • Case Study
      • Case StudyAndrew is a 49-year-old Caucasian male who is seen by a primary care doctor. He reports that for the last 1-2 years or longer, he has experi...
      • Case Study, continuedAndrew is a 49-year-old Caucasian male who is seen by a primary care doctor. He reports that for the last 1-2 years or longer he ...
      • Case Study, continuedAndrew is a 49-year-old Caucasian male who is seen by a primary care doctor. He reports that for the last 1-2 years or longer he ...
  • References

Additional Information

Level of instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, pathology residents, MLS students, and other health care personnel who have an interest in this subject matter.
Author Information: Rebecca J. Laudicina, Ph.D., MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and Ph.D. in Educational Psychology from Temple University. She is the author of numerous publications including many in the field of hematology. 
Reviewer Credentials:
Vicky LeGrys, DA, MLS(ASCP)CM is a professor in the Division of Clinical Laboratory Science in the School of Medicine at the University of North Carolina Chapel Hill where she is responsible for the lecture and laboratory courses in Biochemistry, Clinical Chemistry, and Quality Assurance. She holds a Doctorate of Arts and a Master of Science in Medical Technology from the Catholic University of America, Washington DC with a major in Clinical Chemistry.  
Laurie Bjerklie, M.A., MLS(ASCP)CM is currently a Content Developer for MediaLab and LabCE. She has been in higher education for over 14 years, has been a professor in both MLT and MLS programs, and served as a Program Director.
Course Description: This course offers an in-depth look at the condition of hemochromatosis. It begins with a discussion about normal iron metabolism and continues by explaining the pathophysiology of iron overload that occurs in the condition of hemochromatosis. Clinical considerations and laboratory testing are also discussed.

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 154 CE courses, most popular
$95Add to cart
Pick Your Courses
Up to 8 CE hours
$50Add to cart
Individual course$20Add to cart
Need multiple seats for your university or lab? Get a quote
Iron deposits seen in liver section stained with Prussian blue (1).


Consequences of Iron Overload in HH


HH Signs & Symptoms


Iron Metabolism


Sample Algorithm for HH