Course Outline
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- An Introduction to Chronic Myeloid Leukemia (CML)
- Introduction & Definition of Chronic Myeloid Leukemia (CML)
- Introduction to CML, continued
- Chronic myeloid leukemia (CML) is caused by which of the following?
- The Philadelphia (Ph) chromosome is associated with which of the following chromosomal translocations?
- CML never transforms to acute leukemia.
- The Philadelphia chromosome is only found in the myeloid cell lines and never in the lymphoid cells.
- Epidemiology and Etiology of CML
- Epidemiology & Etiology
- Etiology, continued
- Patients with CML may initially have symptoms of weight loss, low-grade fever, night sweats, or no symptoms at all.
- CML is only a disease of children and is rarely seen in adults.
- Characteristics of CML include which of the following?
- Site of Involvement and Clinical Features for CML
- Peripheral Blood, Blood Smear and Bone Marrow Morphology
- Morphology of the Peripheral Blood Smear
- Morphology of the Bone Marrow Aspirate Smear
- CML - Accelerated Phase (AP)
- CML- Blastic Phase (BP)
- Patients with CML in the chronic phase present with all of the following EXCEPT:
- A patient with CML in the accelerated phase shows which of the following:
- Immunophenotype and Cytogenetics
- Immunophenotyping
- Cytochemical Staining
- Cytogenetics
- Leukocyte alkaline phosphatase activity (LAP score) is very strong in CML and weak in leukemoid reaction.
- Flow cytometry is very valuable in the blastic phase to distinguish myeloid, lymphoid, or mixed phenotype blasts proliferation.
- Differential Diagnosis
- Differential Diagnosis
- Patients with CML and leukemoid reactions present with leukocytosis.
- CML resembles a leukemoid reaction in many ways and is usually resolved with antibiotics.
- Prognosis and Therapy
- Prognosis and Therapy
- Currently, there is no therapy for CML.
- References
Additional Information
Level of instruction: Intermediate
Intended audience: Medical laboratory scientists, medical laboratory technicians, Hematology instructors, MLS students, and other healthcare personnel who have an interest in this subject matter.
Author Information: George Girgis, MLS (ASCP)CM has over 30 years of experience as a Medical Laboratory Scientist, during which he has been a trainer and instructor at Indiana University Health in the field of hematology and hematopathology. George holds a Bachelor of Medicine, Bachelor of Surgery from Ein-Shams University, Cairo, Egypt and a Bachelor of Science in Medical Laboratory Sciences from I.U.P.U.I., Indianapolis, IN.
Reviewer Information:
Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor
of Science and Master of Science in Medical Laboratory Science from Thomas
Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist
and Specialist in Hematology certifications through the ASCP Board of
Certification. He was a professor at Thomas Jefferson University for seven
years before transitioning into his current role as Education Developer at
MediaLab. His areas of expertise and professional passions include clinical
hematology and interprofessional education.
Laurie Bjerklie, MA, MLS(ASCP)CM, is currently an Education Developer for MediaLab and LabCE. She earned a B.S. in Medical Laboratory Science from the University of North Dakota and an M.A. in Curriculum and Instruction from Saint Xavier University. She has over 15 years of experience in higher education and has held program director and faculty positions in both MLT and MLS programs.
