Chronic Myeloid Leukemia (CML) (Online CE Course)

(based on 452 customer ratings)

Author: George Girgis MLS(ASCP) CM
Reviewers: Laurie Bjerklie M.Ed., MT(ASCP) & Margaret A. Reinhart MS, MT(ASCP)

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
Approved through 8/31/2022
Approved through 9/1/2022


  • Define Chronic Myeloid Leukemia (CML).
  • Describe the epidemiology and etiology of CML.
  • Discuss the site of involvement and clinical features of CML.
  • Describe the peripheral blood findings and blood smear morphology for CML cases.
  • Describe the bone marrow morphology in patients with CML.
  • List the disease stages in patients with CML.
  • Discuss immunophenotyping and cytogenetics for CML cases.
  • Outline the prognosis and therapy for patients with CML.

Customer Ratings

(based on 452 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • An Introduction to Chronic Myeloid Leukemia (CML)
      • Introduction & Definition of Chronic Myeloid Leukemia (CML)
      • Introduction to CML, continued
      • Chronic myeloid leukemia (CML) is caused by which of the following?
      • The Philadelphia (Ph) chromosome is associated with which of the following chromosomal translocations?
      • CML never transforms to acute leukemia.
      • The Philadelphia chromosome is only found in the myeloid cell lines and never in the lymphoid cells.
  • Epidemiology and Etiology of CML
      • Epidemiology & Etiology
      • Etiology, continued
      • Patients with CML may initially have symptoms of weight loss, low-grade fever, night sweats, or no symptoms at all.
      • CML is only a disease of children and is rarely seen in adults.
      • Characteristics of CML include which of the following?
  • Site of Involvement and Clinical Features for CML
  • Peripheral Blood, Blood Smear and Bone Marrow Morphology
      • Morphology of the Peripheral Blood Smear
      • Morphology of the Bone Marrow Aspirate Smear
      • CML - Accelerated Phase (AP)
      • CML- Blastic Phase (BP)
      • Patients with CML in the chronic phase present with all of the following EXCEPT:
      • A patient with CML in the accelerated phase shows which of the following:
  • Immunophenotype and Cytogenetics
      • Immunophenotyping
      • Cytochemical Staining
      • Cytogenetics
      • Leukocyte alkaline phosphatase activity (LAP score) is very strong in CML and weak in leukemoid reaction.
      • Flow cytometry is very valuable in the blastic phase to distinguish myeloid, lymphoid, or mixed phenotype blasts proliferation.
  • Differential Diagnosis
      • Differential Diagnosis
      • Patients with CML and leukemoid reactions present with leukocytosis.
      • CML resembles a leukemoid reaction in many ways and is usually resolved with antibiotics.
  • Prognosis and Therapy
      • Prognosis and Therapy
      • Currently, there is no therapy for CML.
  • References
      • References

Additional Information

Level of instruction: Intermediate
Intended audience: Medical laboratory scientists, medical laboratory technicians, Hematology instructors, MLS students, and other health care personnel who have an interest in this subject matter.
Author Information: George Girgis, MLS (ASCP)CM has over 30 years of experience as a Medical Laboratory Scientist during which he has been a trainer and instructor at Indiana University Health in the field of hematology and hematopathology. George holds a Bachelor of Medicine, Bachelor of Surgery from Ein-Shams University, Cairo, Egypt and a Bachelor of Science in Medical Laboratory Sciences from I.U.P.U.I., Indianapolis, IN.
Reviewer Information:  
Laurie Bjerklie, M.Ed., MT(ASCP), is currently a professor at Rasmussen College in Fargo, ND for their MLT program where she teaches a variety of courses including hematology and microbiology. She is the former Program Director of the Clinical Laboratory Science program at DeVry University in Phoenix, Arizona. Bjerklie has over ten years of experience in higher education and continues to work part time as a bench tech.
Margaret Reinhart, MS, MT(ASCP) is the MLS Program Director and Senior lecturer in Biological Sciences at the University of the Sciences in Philadelphia PA where she teaches hematology, clinical immunology, parasitology, and other related courses. She is also adjunct instructor in Hematology at Pennsylvania Hospital, Philadelphia PA. She holds a Masters Degree in Biology and in Health Care Administration.

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 153 CE courses, most popular
$95Add to cart
Pick Your Courses
Up to 8 CE hours
$50Add to cart
Individual course$20Add to cart
Need multiple seats for your university or lab? Get a quote
Bone marrow aspirate is hypercellular.

Philadelphia Chromosome.svg

A diagram depicting Imatinib's therapeutic action (3).

A peripheral blood smear with a mixed phenotype (small & large blast cells).

A peripheral blood smear with basophils and blast cells as noted by arrows.

FISH probe for bcr/ abl fusion in CML