Course Outline
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- Definition and Differentiation of Acute Leukemia from other Neoplastic Disorders.
- Causes and Risk Factors of Acute Leukemia
- Causes of Acute Leukemias: Triggers of Genetic Changes
- Types of Genetic Changes in Acute Leukemia
- Occurrence and Frequency of Acute Leukemia
- Match the genetic or chromosomal abnormality to its definition:
- Introduction to the Classification and Diagnosis of Acute Leukemia
- Classification Systems
- Initial Diagnostic Tests and Samples
- Distinguishing between Acute and Chronic Leukemia
- Differentiation between Myeloid and Lymphoid Lines
- Cytochemical Tests Used in Differentiating Myeloid Cells from Lymphocytic Cells
- Differentiation between Myeloid and Lymphoblastic Leukemias Using Cluster of Differentiation (CD) Markers
- Which of the following cytochemical stains would yield a positive result in AML?
- True or False: The World Health Organization (WHO) classification system relies solely on cell staging, cell morphology, and cytochemical stains.
- Acute Myeloid Leukemia (AML) Diagnosis
- 2016 WHO classification of AML
- Complete WHO AML Classification
- Interpretation of Genetic Designations of the AML Subtypes
- AML FAB Classification
- Occurrence and Common Types of AML
- Match the abbreviation found in the WHO AML designations with the meaning of the designation:
- The WHO classification of AML can be based on all of the following criteria except:
- AML Laboratory Testing
- Basics of Laboratory Testing
- Cytogenetic Analysis
- Molecular Genetics of AML
- Karyotyping used in the diagnosis of AML refers to:
- Mutations that cause AML generally are to the genes that regulate which of the following?
- AML Prognosis and Treatment
- Prognostic Factors of AML
- Types of AML Treatments
- Newer Treatments
- Method of AML Treatment
- Prognosis of AML
- Important factors that can help determine a patient's prognosis of AML include all of the following except:
- What is the mechanism of action of chemotherapeutic drugs known as alkylating agents?
- Acute Lymphoblastic Leukemia (ALL) Diagnosis
- Signs, Symptoms, and Background of ALL
- Diagnosing ALL
- True or False: Adults rarely get ALL; it is typically only found in children.
- 2016 WHO Classification of ALL
- Complete WHO ALL Classification
- FAB Classification
- All of the following are classification criteria in the WHO classification system of ALL except:
- True or False: An essential point of differentiation in the WHO classification system of ALL is whether the disorder is leukemia or lymphoma.
- ALL Laboratory Testing
- Determination of ALL Lineage
- Chromosomal Analysis
- Genetic Analysis
- A three year old has been diagnosed with ALL. Chromosomal analysis performed on this child's lymphocytes showed 53 chromosomes. A true statement about...
- ALL Prognosis and Treatment
- Prognostic Factors for ALL
- Common Cytogenetic Abnormalities and their Prognosis
- Treatment of ALL
- The Future of ALL Therapy
- A three year old is diagnosed with ALL. Choose the characteristics which would yield the most favorable prognosis for this child. Check all that apply...
- Acute Leukemia of Ambiguous Lineage and Blastic Plasmacytoid Dendritic Cell Neoplasm
- Acute Leukemia of Ambiguous Lineage
- Blastic Plasmacytoid Dendritic Cell Neoplasm
- True or False: Acute leukemia of ambiguous lineage (ALAL) is a common leukemia in which the lineage can not be specified or shows features of both lym...
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory
technicians, laboratory supervisors, and laboratory managers. This course is
also appropriate for MLS and MLT students and pathology residents.
Author Information: Margaret Reinhart, MS, MLS(ASCP) is senior lecturer in Biological Sciences at the University of the Sciences in Philadelphia PA and was the MLS Program Director of Medical Laboratory Science from 1990 - January 2020. She currently teaches hematology, clinical immunology, parasitology, and other related courses. She is also adjunct MLS instructor in Hematology at Pennsylvania Hospital (University of Pennsylvania Hospital System), Philadelphia PA. She holds a Masters Degree in Biology and in Health Care Administration.
Reviewer Information: Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor
of Science and Master of Science in Medical Laboratory Science from Thomas
Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist
and Specialist in Hematology certifications through the ASCP Board of
Certification. He was a professor at Thomas Jefferson University for seven
years before transitioning into his current role as Education Developer at
MediaLab. His areas of expertise and professional passions include clinical
hematology and interprofessional education.
