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The page below is a sample from the LabCE course Pituitary Hormones. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Clinical Case Study #2

A 22 year-old male was riding a skateboard without wearing a helmet or protective head gear and collided with a stationary hand rail at a skate park suffering blunt head trauma, brain concussion, loss of consciousness, and temporary loss of memory. During rehabilitation in the hospital, the patient began producing large volumes of urine, (4.5 L/day) even after intravenous fluids had been discontinued.
The physician ordered a battery of tests, including a urine osmolality.
The urine osmolality was 40 mOsm/kg water (reference interval 150-1500 mOsm/kg).
An order for plasma ADH showed a non-detectable level (<0.5 pg/mL) of the hormone.
What is a disease/disorder that could cause the above? Answer is on the next slide.