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Interpretation of HER2 Immunohistochemistry (IHC): Dako HercepTestâ„¢

Scoring guidelines are given by Dako in the Food and Drug Administration (FDA) approved package insert as follows:
ScoreInterpretationDefinition
0NegativeNo staining is observed OR membrane staining is in less than 10% of tumor cells.
1+NegativeA faint, barely perceptible membrane staining is detected in more than 10% of tumor cells. However, only part of the membrane is staining.
2+PositiveA weak to moderate complete membrane staining is observed in more than 10% of the tumor cells.
3+PositiveA strong complete membrane staining is observed in more than 10% of tumor cells.