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Don't Routinely Use Plasma to Reverse Warafarin

It is common practice to transfuse plasma to reduce the effects of warfarin. Vitamin K administration is the treatment of choice. The use of prothrombin complexes or plasma should be reserved for patients who require emergent surgery within 6 hours and those with a major hemorrhage. A large volume of plasma is needed to reverse warfarin causing volume overload in susceptible patients.

Plasma photo by Suzanne Butch