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Classification of Myeloproliferative Neoplasms (MPNs)

MPNs are characterized by marked increases in one or more cell lines within both the peripheral blood and bone marrow due to incorrect regulation of the hematopoietic stem cells. Bone marrow hypercellularity is an important aspect of this group of conditions. Other characteristics that may also be associated with MPNs include cytogenetic abnormalities/acquired mutations, extramedullary hematopoiesis, bone marrow fibrosis, and thrombotic or bleeding episodes. The MPNs are not associated with cellular dysplasia as the myelodystplastic diseases are; which is a helpful differentiation feature. Classifications of the MPNs are based upon which cell line is the most affected along with the patient's history, genetic findings, and laboratory results.

The World Health Organization (WHO) classifies these disorders as myeloproliferative neoplasms:
  • Chronic myelogenous leukemia (BCR/ABL +)
  • Chronic neutrophilic leukemia
  • Chronic eosinophilic leukemia
  • Essential thrombocythemia
  • Primary myelofibrosis
  • Polycythemia vera
  • Mastocytosis
  • Myeloproliferative neoplasm, unclassifiable (MPN-u)