Home Products Most Popular Contact
No items in your cart.
The page below is a sample from the LabCE course Immune Hemolytic Anemias. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Immune Hemolytic Anemias (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 123 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

Possible Serological and Laboratory Presentations

Destruction of red cells (hemolysis) may be intravascular (within blood vessels) or extravascular (outside of blood vessels). Complement causes intravascular hemolysis, which can lead to hemoglobinemia (free hemoglobin in the serum/plasma) and hemoglobinuria (free hemoglobin in the urine). Phagocytosis of red cells by macrophages facilitates extravascular hemolysis, which causes increase in serum bilirubin.
Potential serological/laboratory findings encountered when an immune-mediated anemia is present include:
  • Decreased hemoglobin and hematocrit
  • Spherocytosis
  • Reticulocystosis
  • Possible compensatory increase in nucleated red blood cells
  • Elevated bilirubin and lactate dehydrogenase (LD) levels
  • Decreased haptoglobin
  • Positive DAT due to IgG and/or complement sensitization
  • Positive antibody screen