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Connective Tissue: Type III Collagen

Type III collagen or reticular connective tissue provides the architectural framework for lymphatic tissue and organs such as the liver and spleen. Reticulin fibers form a honeycomb reticulin network where the cell types are deposited and/or anchored, providing structure in organs that can expand. Reticulin fibers cannot be visualized in a hematoxylin and eosin (H&E) stained slide. Reticulin fibers are argyrophilic, meaning that these tissue elements will stain black with a silver solution using the aid of a chemical reducer which brings the silver into to a visible form.