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Examples of Antibodies to Low-Incidence Antigens

Antibodies to low-incidence antigens will be difficult to test for since most screen and panel cells do not have these antigens on the testing cells. Further testing may be needed at a reference laboratory where a larger selection of antibody panels are available to locate cells positive for these antigens.

Suspect an antibody to a low-incidence antigen if:

  • AHG crossmatch is incompatible and
  • Other causes have been ruled out (positive donor DAT, ABO incompatibility)

Examples of antibodies to low-incidence antigens are: anti-V, anti-Cw, anti-Kpa, anti-Jsa, and anti-Lua.