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The page below is a sample from the LabCE course Rh-Negative Female with Anti-D at Delivery: A Case Study (retired 6/11/2018). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Crossmatch Practices Related to RhIg - Introduction

Crossmatch practices for RhIg-derived passive anti-D vary significantly.

Inclusion here does not indicate endorsement or lack thereof for a particular policy, but merely documents that such policies exist. All policies assume the following scenario:

  • An Rh negative female has received antenatal RhIg;
  • She has a positive antibody screen consistent with passive anti-D;
  • A mini-panel has been done to exclude other clinically significant antibodies and shows only anti-D;
  • If performed to detect possible ABO incompatibility, the electronic crossmatch or immediate spin (IS) crossmatch is done with Rh negative RBC whose D typing is confirmed in-house.