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The page below is a sample from the LabCE course Variations in White Cell Morphology -- Granulocytes. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Hyposegmented cells are neutrophils with fewer than three nuclear lobes. The nucleus may be round, peanut-shaped, band-shaped or bilobed. Since nuclear lobe development is abnormal, the chromatin structure often appears more mature than normal. It is sometimes very smooth, almost pyknotic.