Home Products Most Popular Contact
No items in your cart.
The page below is a sample from the LabCE course Alzheimer's Biomarkers: Overview of existing and future biomarkers. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Alzheimer's Biomarkers: Overview of existing and future biomarkers (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 129 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

AD Biomarkers: Key Biomarkers (Continued)

  • Total Tau Protein and Phospho-Tau Protein (P-Tau):
Tau is a family of neuronal proteins that bind to microtubules, which are the neuron's transport system. They help to stabilize the microtubules formation and maintenance. In the human brain, Tau proteins constitute a group of isoforms that normally play a role in the neuron’s transport system to help in transporting nutrients and essential materials.
Interest in Tau proteins began surfacing when research studies demonstrated that tangled forms of the Tau proteins were found in the brains of AD patients. It has been demonstrated that abnormally phosphorylated Tau proteins combined with abnormal shapes of the Tau proteins are the major components of neurofibrillary tangles in AD patients. In turn, the tangles disrupt the neuronal transport system and become toxic to cells leading to neurodegeneration. Research has shown that AD patients tend to have an increase in the CSF level of the total Tau protein and the higher the increase the more intense the neurodegenerative process. Studies have shown that the measurement of total Tau protein and phospho-Tau protein in the CSF may be important biomarkers for the assessment of AD.
Total Tau Protein and Phospho-Tau (P-tau): Studies have found increased total Tau protein and P-tau levels in CSF may be associated with AD. Testing for CSF levels of both total Tau protein and phospho-Tau (P-tau) are available commercially.
Image: The image on ths page shows Tau and Phosphorylated (P-Tau) proteins. Abnormally phosphorylated Tau proteins combined with abnormal shapes of the Tau proteins are the major components of neurofibrillary tangles in AD patients. These tangles disrupt the neuronal transport system and become toxic to cells leading to neurodegeneration