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The page below is a sample from the LabCE course Clostridium difficile Infection (CDI): Overview, Laboratory Tests and Updated Guidelines.. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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CDI: Symptoms and Severity (continued)

Fulminant CDI was previously referred to as severe-complicated CDI. Fulminant CDI is characterized by a severe infection associated with major health complications such as dehydration, hypotension or shock, kidney failure, and other serious conditions. (Complications of CDI are discussed in more detail in a separate section of this course).
Recurrent CDI: In up to 20% of individuals with CDI, the initial infection may recur. Patients on appropriate therapy may have a reappearance of signs and symptoms within 2-8 weeks after treatment has stopped. The clinical presentation may be similar to or more severe than the initial presentation. After two or more recurrences of the infection, the rates of further recurrence increase up to 65% with a recurrence in individuals older than 65, that are taking other antibiotics while being treated for CDI, or have severe medical conditions such as kidney failure, inflammatory bowel disease or chronic liver disease.