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The page below is a sample from the LabCE course Overview Of Major Antigens of the Rh Blood Group System. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Biochemical and Functional Characteristics of Rh

Since the Rh proteins reside exclusively on red blood cells and cross the membrane numerous times, RhD, RhCE, and RHAG proteins make up a critical part of the membrane's integrity. Deletion or alteration of these proteins can lead to structural defects of the red cell membrane, causing decreased survival in the circulation. It has also been shown by Westhoff and colleagues that these proteins may have a functional role in the transport of ammonia.
Harmening, DM,: Modern Blood Banking & Transfusion Practices, 6th ed. FA Davis, Philadelphia, PA, 2012, p 158.
Blaney, KD and Howard, PR: Basic & Applied Concepts of Blood Banking and Transfusion Practices, 3rd ed. Elsevier, St. Louis, MO, 2013, p 108.