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Secondary Hemostasis: The Intrinsic Pathway, continued

3. Then, activated factor IX (IXa), along with ionized calcium, platelet factor, and factor VIII, activate factor X, which is a direct precursor of thrombin in the common pathway. The activation of factor X signals the beginning of the common pathway.
The activated partial thromboplastin time (aPTT) is used to monitor the intrinsic pathway and the effectiveness of heparin therapy.