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The page below is a sample from the LabCE course Drug-Resistant Superbugs, Multi-drug Resistant Organisms: MRSA, VRE, Clostridium difficile, and CRE. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Summary: CRE Versus CP-CRE

CRE are identfied based on disk diffusion or minimum inhibitory concentration (MIC) results (resistant to one of the carbapenems). This testing is sufficient for guiding patient therapy.
CP-CRE are identified based on positive test results (eg, MHT, CarbaNP, CIM) used to confirm the presence of carbapenemase production. If carbapenemase testing is negative, the organism is considerd a CRE. Carbapenemase testing is used only for infection control or epidemiological purposes. Not all CRE are carbapenemase producers. The CP-CRE are of increased epidemiological concern.