CYP450 Induction and Inhibition, continued

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The page below is a sample from the LabCE course Pharmacology for the Clinical Chemist: Therapeutic Drug Monitoring and Pharmacogenomics. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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CYP450 Induction and Inhibition, continued

CYP450InhibitorInducer
CYP1A2
  • Amiodarone
  • Cimetidine
  • Ciprofloxacin
  • Tobacco
CYP2C9
  • Amiodarone
  • Fluvastatin
  • Isoniazid
  • Fluconazole
  • Rifampin
  • Secobarbital
CYP2C19
  • Cimetidine
  • Indomethacin
  • Ketoconazole
  • Prednisone
CYP2D6
  • Celecoxib
  • Cimetidine
  • Cocaine
  • Methadone
  • Pentazocine
  • Imipramine
  • Desipramine
  • Amitriptyline
CYP2E1
  • Disulfiram
  • Fluoxetine
  • Ethanol
  • Isoniazid
CYP3A
  • Midazolam
  • Erythromycin
  • Methadone
  • Phenobarbital
  • Dexamethasone
Note: This is not an exhaustive listing of inducers and inhibitors.
Reference: Tanaka E, Terada M, Misawa S. Cytochrome P450 2E1: its clinical and toxicological role. J Clin Pharm Ther. 2000 Jun;25(3):165-75.