Variations in White Cell Morphology - Granulocytes (Online CEU Course)
Marjorie A. Spahn, MT (ASCP); Barbara Minderman, MT (ASCP)
This course covers all aspects of white blood cell morphology, including identifying changes in morphology in granulocytes. Addresses barr bodies, Dohle bodies, Auer rods, vacuoles, hypersegmented granulocytes, and hyposegmented granulocytes. Excellent as a refresher or for clinical laboratory science students.
Continuing Education Credits
- P.A.C.E.® Contact Hours (acceptable for AMT, ACSP / NCA, and state recertification): 3 hour(s)
- Florida Board of Clinical Laboratory Science CE - General (Hematology): 3 hour(s)
Objectives
- Explain the importance of identifying changes in white cell morphology in granulocytes.
- Define, describe and explain the relationship of Barr bodies to abnormal morphology.
- Discuss nuclear hypersegmentation and hyposegmentation, with respect to:
- definition
- appearance
- composition
- significance
- Discuss nuclear hypersegmentation and hyposegmentation, with respect to:
- hypersegmented granulocytes
- hyposegmented granulocytes
- Be able to identify each of the following cytoplasmic variations:
- Dohle bodies
- Auer rods
- Vacuoles
- Abnormal granulation
Course Outline
Click on a link in the outline to view a sample page from this course.
- Introduction
- Nuclear Variations
- Section Overview
- Hypersegmentation
- Conditions Associated with Hypersegmented Neutrophils
- Hypersegmented Neutrophil
- Another Example of a Hypersegmented Neutrophil
- A Normally Segmented Neutrophil
- Hyposegmentation of Neutrophils
- Conditions Associated with Hyposegmented Neutrophils
- Pelger-Huet Anomaly
- Pelger-Huet Anomaly Does Not Affect Phagocytosis.
- Normal Band Forms vs. Pelger-Huet Bands
- Bilobed Neutrophil
- Single-Lobed Pelger-Huet Cells
- Degenerate Neutrophils in EDTA blood
- Pelger-Huet Cells
- Barr Body
- Barr Bodies may be Normal or Pathological
- Barr Body
- Another Barr Body
- Which of the following statements is true for hypersegmented neutrophils? (Choose ALL of the correct
- Which of the following are seen in Pelger-Huet anomaly? (Choose ALL of the correct answers)
- Choose ALL of the answers that correctly complete the following statement: Barr bodies are important
- Which of the following best describes a Barr body?
- Hyposegmented neutrophils are classified as either pathological or nonpathological.
- Hypersegmented neutrophils are classified as reactive.
- Barr bodies are classified as pathological, nonpathological, and reactive.
- Cytoplasmic Variations
- Cytoplasmic Variations
- Dohle Bodies
- More on Dohle Bodies
- May-Hegglin Anomaly
- Unusually Darkly Staining Dohle Bodies
- Auer Rods
- Auer Rod
- Auer Rods
- Cytoplasmic Vacuolation
- Cytoplasmic Vacuolation
- Smaller Vacuoles
- Toxic Granulation
- Neutrophil with Normal Granulation
- Band Neutrophil Showing Toxic Granulation
- Another Example of Toxic Granulation
- Dohle Bodies and Toxic Granulation
- Classification
- Inherited Anomalies
- Chediak-Higashi
- Albinism
- Granules in Chediak-Higashi Syndrome versus Toxic Granulation
- Neutrophil with Chediak-Higashi
- Neutrophil with Chediak-Higashi
- Toxic Granulation
- Lymphocyte with Chediak-Higashi
- Alder-Reilly Anomaly (Alder's Anomaly)
- Alder-Reilly Neutrophil
- Alder-Reilly Anomaly
- Which of the following inclusions have a similar appearance on a Wright's stained smear?
- A vacuole may contain:
- The inclusions that can be of diagnostic significance when seen in the cytoplasm of myeloblasts are:
- Toxic granulation is seen most frequently in:
- The inclusions that are frequently seen on the same slide with toxic granulation include: (Choose AL
- Match each of the following. Answers may be used more than once or not at all.
- Match each of the following. Answers may be used more than once or not at all.
- Auer rods are significant when they are seen in the cytoplasm of blast cells because they are diagno
- Chediak-Higashi is characterized by:
- Alder-Reilly is characterized by:
- Which morphologic term describes this slide?
- Which morphologic term describes this slide?
- Which morphologic term describes this slide?
- Which morphologic term describes this slide?
- Which morphologic term describes this slide?
- Which morphologic term describes this slide?
Additional Information
Level of instruction: Intermediate
Intended Audience: Clinical Laboratory Science Students, and medical technologists and technicians seeking review or continuing education. It is also appropriate medical students and pathology residents, and pathologists.
Course Description: This course covers morphologic variations seen in granulocytes, including nuclear and cytoplasmic variations.
Authors: by Marjorie A. Spahn, MT (ASCP); Barbara Minderman, MT (ASCP, updated by EMHP, and reviewed and adapted for the web by Paul Fekete, M.D. C.A.P AP/CP.
About the Course: This course is part of a series of courses adapted for the web by MediaLab, under license from Education Materials for Health Professionals, Inc. Dayton OH, 45420. Copyright EMHP.
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