Variations in White Cell Morphology - Granulocytes (Online CE Course)
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Marjorie A. Spahn, MT (ASCP); Barbara Minderman, MT (ASCP)
This course covers all aspects of white blood cell morphology, including identifying changes in morphology in granulocytes. Addresses barr bodies, Dohle bodies, Auer rods, vacuoles, hypersegmented granulocytes, and hyposegmented granulocytes. Excellent as a refresher or for clinical laboratory science students.
Continuing Education Credits
- P.A.C.E.® Contact Hours (acceptable for AMT, ACSP / NCA, and state recertification): 3 hour(s)
- Florida Board of Clinical Laboratory Science CE - General (Hematology): 3 hour(s)
Objectives
- Explain the importance of identifying changes in granulocyte morphology.
- Define, describe, and explain the relationship of Barr bodies to abnormal morphology.
- Discuss nuclear hypersegmentation and hyposegmentation, with respect to: definition, appearance, composition, and significance.
- Discuss nuclear hypersegmentation and hyposegmentation, with respect to: hypersegmented granulocytes and hyposegmented granulocytes.
- Identify each of the following cytoplasmic variations: Dohle bodies, Auer rods, vacuoles, and abnormal granulation.
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Course Outline
- Introduction
- Variations in Morphology
- Importance of Recognition
- Match the following:
- All of the following are important reasons to identify cell changes EXCEPT:
- Nuclear Variations
- Section Overview
- Hypersegmentation
- Conditions Associated with Hypersegmented Neutrophils
- Hypersegmented Neutrophils
- Hypersegmented Neutrophils (cont.)
- A Normally Segmented Neutrophil
- Hypersegmented neutrophils are classified as reactive.
- Which of the following statements is true for hypersegmented neutrophils? (Choose ALL of the correct answers)
- Hyposegmentation
- Conditions Associated with Hyposegmented Neutrophils
- Pelger-Huet Anomaly
- Normal Band Forms vs. Pelger-Huet Bands
- Bilobed Neutrophil
- Pelger-Huet Cells
- Single-Lobed Pelger-Huet Cells
- Which of the following are seen in Pelger-Huet anomaly? (Choose ALL of the correct answers)
- Barr Body
- Barr Body (cont.)
- Which of the following best describes a Barr body?
- Cytoplasmic Variations
- Cytoplasmic Variations
- Dohle Bodies
- Dohle Bodies (cont.)
- May-Hegglin Anomaly
- Which of the following inclusions have a similar appearance on a Wright's stained smear?
- Unusually Darkly Staining Dohle Bodies
- Auer Rods
- Auer Rods (cont.)
- The inclusions that can be of diagnostic significance when seen in the cytoplasm of myeloblasts are:
- Auer rods are significant when they are seen in the cytoplasm of blast cells because they are diagnostic for:
- Cytoplasmic Vacuolation
- Toxic Granulation
- Neutrophil with Normal Granulation
- Band Neutrophil Showing Toxic Granulation
- Toxic Granulation and Vacuolation
- Inherited Anomalies: Chediak-Higashi Syndrome
- Albinism and Chediak-Higashi Syndrome
- Chediak-Higashi syndrome vs. Toxic Granulation
- Chediak-Higashi syndrome Neutrophil
- Chediak-Higashi syndrome is characterized by:
- Which morphologic term describes the condition that could be present judging by the cell in this image?
- Toxic Granulation
- Toxic granulation is seen most frequently in:
- The inclusions that are frequently seen on the same peripheral blood smear with toxic granulation include: (Choose ALL that apply)
- Which morphologic term describes the cellular morphology in this image?
- Chediak-Higashi Syndrome Lymphocyte
- Alder-Reilly Anomaly (Alder's Anomaly)
- Alder-Reilly Neutrophil
- Alder-Reilly Anomaly
- Alder-Reilly is characterized by:
Additional Information
Level of instruction: Intermediate
Intended Audience: clinical laboratory science students, medical technologists, and medical laboratory technicians seeking review or continuing education. It is also appropriate for medical students, pathology residents, and pathologists.
Course Description: This course covers morphologic variations observed in granulocytes, including nuclear and cytoplasmic variations.
Authors: by Marjorie A. Spahn, MT (ASCP); Barbara Minderman, MT (ASCP, updated by EMHP, and reviewed and adapted for the web by Paul Fekete, M.D. C.A.P AP/CP.
About the Course: This course is part of a series of courses adapted for the web by MediaLab, under license from Education Materials for Health Professionals, Inc. Dayton OH, 45420. Copyright EMHP.
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