Metabolic Syndrome (Online CE Course)
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Author: Mary Ellen Koenn, MS, MT(ASCP), CLS(NCA)
Reviewer: Leslie Lovett, MS, MT(ASCP)
This course discusses the metabolic syndrome, a diagnosis that is not associated with one particular disease, but rather the probability of developing certain diseases or disorders as a result of a combination of defined risk factors. Explanations are presented about the inter-relationship between cytokines produced by adipose tissue and metabolic syndrome risk factors. Laboratory tests that are used to detect and monitor metabolic syndrome are also discussed.
Continuing Education Credits
- P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1 hour(s)
- Florida Board of Clinical Laboratory Science CE - General (Clinical Chemistry/UA/Toxicology): 1 hour(s)
Objectives
- Identify the risk factors for metabolic syndrome.
- List other diseases and medical complications associated with metabolic syndrome.
- Describe the impaired lipid metabolism that occurs in metabolic syndrome and how it affects carbohydrate metabolism and produces an atherogenic dyslipidemia.
- Explain the role of insulin resistance and obesity in the onset of metabolic syndrome.
- Describe the role of the laboratory in diagnosis and monitoring patients diagnosed with metabolic syndrome.
- Interpret patient information and laboratory results using the NCEP: ATP III metabolic syndrome criteria and laboratory reference ranges.
- Briefly describe clinical treatment goals in metabolic syndrome.
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Course Outline
- Metabolic Syndrome
- Introduction
- Metabolic Syndrome
- Other Names for Metabolic Syndrome
- Medical Complications of Metabolic Syndrome
- The Importance of Diagnosing Metabolic Syndrome
- An individual diagnosed with metabolic syndrome has an increased risk for developing cardiovascular disease and/or type 2 diabetes.
- Which of the following are possible medical complications for an individual diagnosed with metabolic syndrome?
- Risk Factors for Metabolic Syndrome
- Risk Factors
- Insulin Resistance
- Obesity
- Other Contributing Factors
- Adipose tissue and metabolic syndrome
- Adipose Tissue as an Endocrine System
- Role of Adipokines
- Adipokines Significant to Metabolic Syndrome
- TNF-alpha
- IL-6
- PAI-1
- Adiponectin
- Angiotensinogen
- Leptin
- Resistin
- Which adipokine is synthesized and released by adipocytes and many other body cell types, is an inflammatory cytokine that stimulates the liver to pro...
- Which adipokine is decreased in obesity, is anti-inflammatory, and increases insulin sensitivity?
- Diseases Associated with Metabolic Syndrome
- Cardiovascular Disease
- Adipokines and Atherosclerotic Inflammatory Process
- Adipokines and Atherosclerotic Inflammatory Process Continued
- Endothelial Dysfunction
- Which adipokines advance atherosclerosis by enhancing cell adhesion in vessel walls?
- Dyslipidemia
- Dyslipidemia and Metabolic Syndrome
- Small Dense LDL Molecules
- Atherogenic Dyslipidemia
- Which lipid group in increased concentrations probably decreases HDL-C and causes the formation of small dense LDL molecules?
- Why are small dense LDL molecules more atherogenic?
- Type 2 Diabetes
- Hypertension
- Prothrombotic State
- Proinflammatory State
- C-Reactive Protein (CRP)
- CRP Measurement
- Insulin resistance places an individual with metabolic syndrome at greatest risk for
- Which of the following most likely causes the hypertension that often occurs in metabolic syndrome?
- Which condition is caused by the increased PAI-1 and fibrinogen often present in metabolic syndrome?
- Which assay is a more recent marker of chronic inflammation and is used for cardiac risk assessment?
- Diagnosis of Metabolic Syndrome
- Variation in Diagnostic Criteria
- Adult Treatment Panel III
- NCEP: ATP III Diagnostic Criteria for Metabolic Syndrome
- At medical examination, a 50-year-old Caucasian male expressed concern regarding diabetes. There is a history of type 2 diabetes, hypertension, and ca...
- Clinical Management in Metabolic Syndrome
- Treatment
- Magnesium, Calcium, and Vitamin D
- Low-dose aspirin and antiplatelet agents may reduce the risk of diabetes for those diagnosed with metabolic syndrome.
- Laboratory Role in Metabolic Syndrome
- Clinical Laboratory Testing in Metabolic Syndrome
- Analytes and Target Ranges Pertinent to Metabolic Syndrome
- A 45-year-old African American female has been diagnosed and treated for type 2 diabetes for the past five years. She maintains good control of her bl...
- A physician discusses weight with an overweight 60-year-old female at her yearly physical appointment. The female exercises regularly and eats healthy...
- References
Additional Information
Level of instruction: Intermediate
Intended Audience: Clinical laboratory technologists and technicians, and other health care personnel who have an interest in this subject matter. This course is also appropriate for clinical laboratory science students and pathology residents. Author information: Mary Ellen Koenn, MS, MT(ASCP), CLS(NCA) is an associate professor at West Virginia University School of Medicine in the Medical Technology Program. During her career as a medical technologist and educator, she has been a laboratory supervisor and manager and has held several teaching positions. She is active in the American Society for Clinical Laboratory Science (ASCLS), resulting in a nomination as ASCLS Member of the Year in 2006. She is also a member of the American Association for Clinical Chemistry. She is the author of numerous articles for laboratory publications and textbook chapters and is a frequent presenter at laboratory seminars and workshops. Ms. Koenn holds a Master of Science degree in Medical Technology. Reviewer information: Leslie Lovett, MS, MT(ASCP) is the Clinical Education Coordinator of the Medical Laboratory Technology Program and a professor at Pierpont Community and Technical College in West Virginia. She holds a MS degree in Medical Technology with classes toward a PhD in Pharmacology and Toxicology. Course description: This course discusses the metabolic syndrome, a diagnosis that is not associated with one particular disease, but rather the probability of developing certain diseases or disorders as a result of a combination of defined risk factors. Explanations are presented about the inter-relationship between cytokines produced by adipose tissue and metabolic syndrome risk factors. Laboratory tests that are used to detect and monitor metabolic syndrome are also discussed.
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