The page below is a sample from the LabCE course Antiplatelet Medication Response Testing: Aspirin and Clopidogrel. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Aspirin Dosing

Daily low doses of aspirin are most commonly prescribed to patients with a high risk of thrombi production to produce an antiplatelet effect. When aspirin is given in low doses (75-150 mg/day), the maximal antiplatelet effect may take several days. At a dose of 160-325 mg/day, the maximal antiplatelet effect of aspirin is faster and can occur in approximately 30 minutes. Therefore, aspirin at low doses is prescribed for the long-term prevention of heart attacks and strokes and moderate doses are given in situations where an immediate anti-clotting effect is needed.

Low-Dose (~75-150 mg/day) Recommendations:
  • Patients undergoing surgery to open or bypass blocked arteries
  • Patients who have previously had heart attacks or strokes
  • Patients with risk factors, such as diabetes
  • Patients with peripheral vascular disease
Moderate-Dose (~160-325 mg/day) Recommendations:
  • During a myocardial infarction
  • Patients who are experiencing unstable angina
  • Patients who are experiencing ischemic strokes