The page below is a sample from the LabCE course HER2 Testing in Breast Cancer. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Test Systems Without a Chromosome 17 Centromere Signal to Enumerate

For a test system that does NOT have a chromosome 17 centromere signal to enumerate:

  • Normal HER2 gene copy number - An average of fewer than four copies of HER2 gene per nucleus for systems without an internal control probe.
  • Amplified HER2 gene copy number - 4 to 6 gene copies/nucleus for test systems without internal control probe.