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The page below is a sample from the LabCE course Tuberculosis Awareness for Health Care Workers. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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High-Risk Progression Groups

The following persons are at high risk for progression from LTBI to TB disease:

  • Persons infected with HIV (20-30 times more likely to develop active TB)
  • Persons infected with Mycobacterium tuberculosis within the past two years
  • Persons with untreated or inadequately treated TB disease
  • Infants and children <4 years of age (Babies and young children often have weak immune systems)
  • Persons with chronic medical conditions or immunocompromising conditions including:
    • Substance abuse
    • Silicosis
    • Diabetes mellitus
    • Severe kidney disease
    • Low body weight
    • Organ transplants
    • Head and neck cancer
    • Medical treatments such as corticosteroids or organ transplant
    • Specialized treatment for rheumatoid arthritis or Crohn's disease