The page below is a sample from the LabCE course Hemoglobinopathies: Hemoglobin S Disorders. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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CBC and RBC Morphology

CBC results for patients with sickle cell disease who have a hereditary persistence of fetal hemoglobin (Hb S/HPFH) may appear normal or demonstrate a mild to moderate anemia. The CBC and peripheral blood smear for a patient with Hb S/HPFH appear below.

Reference intervals may vary between facilities and are dependent on patient age and gender. The reference intervals that are shown below are specific to this case.
Parameter
Patient Result
Reference Interval
White blood cell count (WBC)6.43.8 - 9.8 x 109/L
Red blood cell count (RBC)4.784.50 - 5.90 x 1012/L
Hemoglobin
11.913.8 - 17.2 g/dL
Hematocrit37.741 - 50%
MCV8180 - 100 fL
RDW13.212 - 14.6
Platelet count230140 - 440 x 109/L