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The page below is a sample from the LabCE course Hemoglobinopathies: Hemoglobin S Disorders. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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CBC and RBC Morphology

Patients with double heterozygous hemoglobin SC disease (Hb SC) may have a slight to moderate anemia. The CBC and peripheral blood smear for an adult patient with Hb SC appear below. The arrow in the image of the peripheral blood smear is pointing to a Hb SC crystal.

Reference intervals may vary between facilities and are dependent on patient age and gender. The reference intervals that are shown below are specific to this case.
Patient Result
Reference Interval
White blood cell count (WBC)10.44.5 - 11.0 x 109/L
Red blood cell count (RBC)3.984.50 - 4.70 x 1012/L
10.511.7 - 16.0 g/dL
Hematocrit33.535 - 47%
MCV8481 - 101 fL
RDW16.011 - 14.5
Platelet count160150 - 450 x 109/L