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SCD can be accompanied by various physical and emotional/mental complications. Physical complications may include:

  • Acute chest syndrome
  • Blindness
  • Cardiomegaly
  • Cerebrovascular accident
  • Chronic organ damage
  • Chronic pain
  • Chronic skin ulceration
  • Hematuria and renal dysfunction
  • Hepatomegaly
  • Infections and sepsis
  • Necrosis of bone marrow, bone, and joints
  • Osteomyelitis
  • Priapism
  • Pulmonary arterial hypertension
  • Stroke
In addition, post-treatment complications that result from repeated transfusions and pharmacotherapy may also occur.

Emotional complications include anxiety and depression.