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The page below is a sample from the LabCE course Hemoglobinopathies: Hemoglobin S Disorders. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Normal and Hb S Beta Chain DNA Base Sequences

Each amino acid is coded for by a sequence of three bases. The gene for the beta chain contains the code for a sequence of 146 amino acids. The first six of these amino acids are: valine, histidine, leucine, threonine, proline, and glutamic acid.
The specific base sequence for these amino acids is: GTG/CAC/CTG/ACT/CCT/GAG.

Normal Human Beta Chain (first six codons)
Val HisLeu ThrPro Glu

Sickle cell hemoglobin (Hemoglobin S) results when, glutamic acid that is normally present in the sixth position on the beta globin chain is substituted with valine.
Sickle Cell Hemoglobin (first six codons)
ValHisLeu Thr ProVal
6glu-val" in the nomenclature indicates this mutation in the sixth position on the beta chain.