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The page below is a sample from the LabCE course Laboratory Assessment of Thyroid Function (retired 3/27/2020). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Analysis of Thyroperoxidase Antibody (TPOAb)

The determination of TPOAb levels is considered as a sensitive test for detecting autoimmune thyroid disease. The highest TPOAb levels are observed in patients suffering from Hashimoto's thyroiditis. In this disease, the prevalence of TPOAb is about 90% of cases confirming the autoimmune origin of the disease. These autoantibodies also frequently occur (60–80%) in the course of Graves’ disease. In addition to autoimmune thyroid disease states, detectable concentrations of TPOAb are often detected in the sera of type I insulin-dependent diabetics.
The analysis of TPOAb is most commonly achieved through immunoassay methods employing the principles of ELISA and chemiluminescence.