The success of a patient blood management program is dependent on multiple individuals making changes in clinical practice to reduce the likelihood of transfusion. Each intervention method can be implemented independently in the order that makes sense for the institution. The clinical laboratory plays a vital role in preventing unnecessary transfusion by providing laboratory data, determining specimen collection policies and procedures, identifying patients that require review by the Patient Blood Management Team and making suggestions for improvement. Not every facility will adopt every technique. The process is step-wise and carefully planned to enhance the prospects for success.