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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Basic Laboratory Tests of Hemostatic Function – Fibrinogen Assay

  • The fibrinogen assay performed in the clinical laboratory is a quantitative measure of factor I.
  • This assay is used to determine whether there is enough fibrinogen present to allow for normal clotting.
  • It is performed in cases of an unexpected, prolonged bleeding event, or an unexpected abnormal PT and/or APTT.
    • Additionally, it is also used to aid in the diagnosis of disseminated intravascular coagulation (DIC).
  • A normal reference range is typically around 200-400 mg/dl.
    • That range is significant because fibrinogen levels <100 mg/dl are often associated with free bleeding, or impaired hemostatic function.