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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Secondary Hemostasis – The Common Pathway

  • Thrombin, after its conversion from prothrombin, catalyzes the conversion of fibrinogen into a fibrin monomer.
  • Additionally, thrombin triggers the conversion of factor XIII into factor XIIIa which forms covalent bonds that crosslink and stabilize the fibrin monomers.
  • Finally, thrombin feeds back into the intrinsic and common pathways, accelerating the action of factors XI, V, and VIII.