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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Secondary Hemostasis – The Intrinsic Pathway

  • Then, activated factor IX (IXa), along with ionized calcium, platelet factor, and factor VIII, activate factor X, which is a direct precursor of thrombin in the common pathway.
  • The activation of factor X signals the beginning of the common pathway.
  • The activated partial thromboplastin time (APTT) is used to monitor the intrinsic pathway and the effectiveness of heparin therapy.