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Secondary Hemostasis – Fibrin Formation via the Coagulation Cascade
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Secondary Hemostasis – Fibrin Formation via the Coagulation Cascade
The formation of fibrin involves three interconnected biochemical pathways; the
intrinsic
,
extrinsic
, and
common
pathways.
These pathways allow for the interaction of coagulation factors via a finely tuned sequence of chemical processes, where the factors themselves control the activity of the pathway.
Most coagulation factors are stimulated and activated by the
preceding
factor , hence the term, "coagulation cascade."
Since factor activation requires the activation of a preceding factor, a deficiency in the functionality
or
availability of any factor would seriously impact the effectiveness of the coagulation process.
Factor deficiencies do occur, however, and often lead to impaired vascular repair and depressed hemostatic activity.
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