Groups l and lll ABO discrepancies are plasma-mediated discrepancies. Examples of conditions/situations that can result in these ABO discrepancies include:
Group l-- Discrepancies that are associated with missing/atypically weakened reactions in the reverse typing.
- Weakened or missing antibodies
- Leukemic patients, immunosuppressed
- Diluted antibodies due to transfusion
- Geriatric or neonatal patients
-- Discrepancies between forward and reverse typing caused by protein or plasma abnormalities, resulting in unexpected reactions in the reverse typing.
- Gammopathies such as multiple myeloma
- Increased fibrinogen
- Plasma expanders
- Cord blood samples containing Wharton's jelly