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The page below is a sample from the LabCE course ABO Typing Discrepancies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Plasma-Mediated ABO Discrepancies

Groups l and lll ABO discrepancies are plasma-mediated discrepancies. Examples of conditions/situations that can result in these ABO discrepancies include:

Group l-- Discrepancies that are associated with missing/atypically weakened reactions in the reverse typing.
  • Weakened or missing antibodies
  • Leukemic patients, immunosuppressed
  • Diluted antibodies due to transfusion
  • Geriatric or neonatal patients
Group lll-- Discrepancies between forward and reverse typing caused by protein or plasma abnormalities, resulting in unexpected reactions in the reverse typing.
  • Gammopathies such as multiple myeloma
  • Increased fibrinogen
  • Plasma expanders
  • Cord blood samples containing Wharton's jelly