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The page below is a sample from the LabCE course Laboratory Diagnosis of Cystic Fibrosis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Reference Intervals for Sweat Chloride

Sweat chloride concentrations can increase slightly with age so there are age-related reference intervals. Sweat chloride concentrations should always be interpreted with regards to the clinical situation and the knowledge that some rare CF-causing mutations of CFTR can be associated with chloride values in the normal and intermediate ranges.
Diagnostic interpretations for infants up to and including 6 months of age

Chloride Concentration
Diagnostic Interpretation
< 29 mmol/L
CF unlikely
30-59 mmol/L
Intermediate (CF is possible)
> 60 mmol/L
Indicative of CF

Diagnostic interpretations for patients over 6 months of age

Chloride Concentration
Diagnostic Interpretation
< 39 mmol/L
CF unlikely
40-59 mmol/L
Intermediate (CF is possible)
> 60 mmol/L
Indicative of CF