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Specific Proteins as Tumor Markers - Diagnostic Utility

While the detection of a monoclonal paraprotein is strongly associated with the presence of a malignant plasma cell tumor, the appearance of nonmalignant monoclonal immunoglobulins increases with age, with a prevalence as high as 5% in those over age 75. In nonmalignant cases, the immunoglobulin concentrations are typically lower than observed in malignant cases.2