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The page below is a sample from the LabCE course Tumor Markers. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Specific Proteins as Tumor Markers - Monoclonal Immunoglobulins

In this agarose gel electrophoresis, the lane indicated by the arrow represents a monoclonal immunoglobulin. Monoclonal paraproteins appear as sharp bands in the globulin area of the serum electrophoresis patterns. In this particular case, the patient was subsequently diagnosed with an immunoglobulin G (IgG) multiple myeloma.
A multiple myeloma is a malignant neoplasm of a single clone of plasma cells of the bone marrow. The most common monoclonal immunoglobulin in multiple myelomas is an IgG paraprotein.