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The page below is a sample from the LabCE course Technical Preparation of Bone Marrow Specimens for Histological Assessment. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Mastocytosis in bone marrow demonstrated with CD117

CD117 or Mast Cell Tryptase Stains

There is a very low degree of infiltration of the bone marrow in most cases of systemic mastocytosis, which is the presence of too many mast cells or mastocytes. For this reason, CD117 (shown in the image on right) and mast cell tryptase stains are used to look for and quantitate mast cells, which would be seen in systemic mastocytosis.

The image below demonstrates mastocytosis in bone marrow shown in an H&E stained section.