The page below is a sample from the LabCE course Detecting and Evaluating Coagulation Inhibitors and Factor Deficiencies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Further Analyses for Coagulation Inhibitors- Lupus Anticoagulant

For the diagnosis of lupus anticoagulant, the International Society on Thrombosis and Hemostasis has set a protocol of diagnostic criteria that should be met. This includes the following requirements:

  1. The patient sample must show abnormal phospholipid-dependent reactions in the coagulation lab.
  2. The patient sample must show inhibition of clotting after the mixing study test has been performed.
  3. The patient sample must be proven to have an inhibitor and not a factor deficiency.
  4. The patient must have a definitive phospholipid-dependent antibody and not a specific factor inhibitor.