The page below is a sample from the LabCE course Detecting and Evaluating Coagulation Inhibitors and Factor Deficiencies. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Interpreting the Mixing Study Results

Interpretation patterns for mixing study results include the following scenarios:
  1. If the results of the mixing study show correction for both the immediate and incubated PT/aPTT tests, the patient most likely has a factor deficiency (or multiple factor deficiencies).
  2. If the results of the mixing study show no correction in either the immediate or incubated PT/aPTT, the patient may have a coagulation inhibitor, most likely a lupus anticoagulant.
  3. If the results of the mixing study show correction for the immediate PT/aPTT results, but no correction in the incubated PT/aPTT, the patient may have a slow-acting inhibitor such as anti-factor VIII.
Note: if the control tubes also show prolongation after incubation, there may have been a problem with the heat-labile factors in the sample losing their activity. If this is the case, the mixing study should be repeated.