Drug-induced immune hemolytic anemia is a rare category of autoimmune hemolytic anemias. Antibodies produced in response to a medication, or its metabolite, are the cause of the hemolytic anemia. The drug may cause a positive DAT, which may or may not be associated with immune hemolysis. Patients may present with similar serological and laboratory findings as the other types of autoimmune hemolytic anemias, and may be difficult to differentiate. Accurate medication history is beneficial in resolution of the serologic presentation.