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The page below is a sample from the LabCE course Liver Biopsies: Anatomy and Histological Considerations. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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A liver biopsy section demonstrating several forms of artifact such as chatter, folds, and sponge artifact.

Artifacts

As in any specimen, liver biopsies are subject to microtomy artifacts.
Examples of artifacts are:
  • Folds or creases in the tissue section
  • Formalin pigment
  • Section compression
  • Waterbath contaminants
  • Knife lines
  • Chatter from rapid sectioning
  • Chatter from improper rehydration of tissue