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The page below is a sample from the LabCE course Technical Competence in Paraffin-Based Fluorescence In Situ Hybridization (FISH). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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International Standing Committee on Cytogenetic Nomenclature (ISCN) Reporting

Understanding the nomenclature of cytogenetics is very important in reporting patient FISH results correctly.
The ISCN "string" is the sentence that describes the cytogenetic findings in ISCN format.
For FISH, the generic "string" is as follows: Interphase FISH is Nuc ISH is (gene location X range of signals observed)(gene location X range of signals observed)[number of cells counted].
For example, for a HER2/neu assay in breast cancer, the ISCN string would be:
Interphase FISH is Nuc ISH is (DZ17 x 1-3)( x 3-8)[60].