The page below is a sample from the LabCE course Pharmacology in the Clinical Lab: Therapeutic Drug Monitoring and Pharmacogenomics. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Pharmacology in the Clinical Lab: Therapeutic Drug Monitoring and Pharmacogenomics (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 97 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

Enzyme Abnormalities and Drugs

Not all PGx is concerned with CYP450 enzymes. There are other drug-metabolizing enzymes that show polymorphisms and can affect the way people respond to a drug. The following is a list of enzymes for which known mutations have been associated with clinical effects.
Enzymes
Substrates (Drugs)
Acetylaldehyde dehydrogenaseAlcohol
Acetylcholinesterase
Succinylcholine
Alcohol dehydrogenaseAlcohol
Dihydropyrimidine dehydrogenase Fluorouracil
CYP2C9Warfarin, phenytoin, losartan
CYP2C19Diazepam, omeprazole (Prilosec)
CYP2D6Many antidepressants, opioids, antiarrhythmics
Glucose-6-phosphate dehydrogenase Aspirin, quinidine
N-acetyltransferase Procainamide, isoniazid
Thioprine methyltransferase 6-mercaptopurine
UDP-glucuronosyl transferase Acetaminophen, tolbutamide, irinotecan