The page below is a sample from the LabCE course Pharmacology in the Clinical Lab: Therapeutic Drug Monitoring and Pharmacogenomics. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Pharmacology in the Clinical Lab: Therapeutic Drug Monitoring and Pharmacogenomics (online CE course) »
How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 101 CE courses, most popular
$95 Add to cart
Pick Your Courses
Up to 8 CE hours
$50 Add to cart
Individual course$20 Add to cart

Polymorphism and CYP450

To discuss PGx, we must first define two terms:
  1. Polymorphism
  2. Cytochrome P450 (CYP450)
A polymorphism is a variation in a specific gene (allele) that affects at least 1% of the population. It is essentially a mutation that occurs relatively frequently in the population.
CYP450 refers to a family of enzymes found predominantly in the liver. CYP450 enzymes work on a variety of substrates (in this case, drugs), altering their chemical structures to facilitate excretion in the urine and feces. Many polymorphisms occur in the protein sequences of CYP450 enzymes.