The page below is a sample from the LabCE course Pharmacology in the Clinical Lab: Therapeutic Drug Monitoring and Pharmacogenomics. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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TDM for Antibiotics

Infection is obviously a very serious indication, and effective antibiotic levels must be achieved as soon as possible. However, many antibiotics also have nephrotoxic or ototoxic effects; the concentrations of these antibiotics need to be monitored. Serum concentrations that are too low or too high must be avoided.
Examples of antibiotics that are monitored by TDM include:
  • Amikacin
  • Gentamicin
  • Tobramycin
  • Vancomycin
Antibiotics such as ampicillin that are readily cleared and have a wide therapeutic window are not usually monitored by TDM.