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The page below is a sample from the LabCE course Immunohistochemistry (IHC) - Detection and Identification of Infectious Disease Processes in Surgical Pathology. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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BK Polyomavirus (BKV)

BK polyomavirus (BKV), a DNA virus, is the second of two polyoma species. BKV infects a variety of urinary tract epithelia in immunocompromised patients and with increased frequency, patients with nephropathy and rejection renal transplant recipients. Use of the anti-SV40 monoclonal antibody, clone MRQ-4 will usually result in dense nuclear localization of the polyomavirus within renal tubules and urothelial cells. SV40 requires heat-induced epitope retrieval (HIER) pretreatment with citrate buffer (Ref4).
In the top image, SV40 antibody is reacting with BKV positive renal tubules from a renal transplant patient, utilizing DAB chromogen. In the lower image, SV40 antibody reacts with BKV positive renal tubules from a renal transplant patient, again using DAB chromogen.