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Gordon and Sweet's Silver Staining - Diagnostic Applications

Reticular fibers support body organs like the liver, spleen, and kidneys. The Gordon and Sweet's silver staining method is used to demonstrate abnormal reticular fiber patterns that may indicate cirrhosis or necrosis of the liver. This is why reticular stains are often requested on liver biopsies. Abnormal reticular fiber patterns may also indicate the presence of certain tumor types in the liver, spleen, or kidneys.